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Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.
BetMGM NFL Odds: 49ers by 2 1/2. Series record: 49ers lead 37-31. Against the spread: 49ers 5-5; Cardinals 5-4. Last week: Rams beat 49ers 42-26; Seahawks beat Cardinals 44-22. Last meeting: 49ers beat Cardinals 16-15 on Sept. 21, 2025, in Santa Clara ...
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49ers vs. Cardinals highlights: San Francisco blows out NFC West rival in big game
The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.
Walter Nolen III, a defensive tackle out of Ole Miss, was scouted by the 49ers, who instead took Mykel Williams with the No. 11 pick in the first round. Nolen went to the Cardinals at No. 16 and didn’t make his debut until two weeks ago because of a late-July calf injury.
The San Francisco 49ers are getting healthy at long last, but their luck may be running out ahead of today’s NFC West showdown with the Arizona Cardinals. My 49ers vs. Cardinals predictions detail why Arizona should be respected more in this spot, and ...