A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...
Figure 1: Delta-Notch and d-Asb11 function in a positive-feedback loop. Figure 3: d-Asb11 binds to the Notch regulator Nrarp and the Notch ligand DeltaA. Figure 5: Activation of Notch reporters by ...
While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...
Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...
Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds its ligands Delta and Serrate ...
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