The Cardinals are also without their backup running back, rookie Trey Benson. He suffered an ankle injury in Week 16 and was placed on injured reserve earlier this week. Emari Demercado, their third-down back, is also on injured reserve with a back injury suffered in early December.

Conner has not yet gone in the blue medical tent or headed to the Cardinals locker room. Last week, he exited with his initial injury in the third quarter and did not return, despite never going to the locker room.

The Arizona Cardinals had a walkthrough Wednesday in advance of Sunday’s game against the San Francisco 49ers, so the injury report is an estimate.

Arizona Cardinals running back James Conner has been ruled out of Sunday's game against the San Francisco 49ers due to a knee injury, coach Jonathan Gannon said Wednesday. Conner, 29,