In 1775, English surgeon Percivall Pott discovered that exposure to soot in chimneys caused scrotal cancer in chimney sweeps, the first time an agent found in the workplace was directly connected to ...

Cervical cancer is the fourth leading cause of cancer deaths in women worldwide. Although the disease is driven by two antigenic viral oncoproteins, therapeutic vaccines have proved ineffective, ...

Tumor initiation, via either chemical mutagens or genetic models of Ras activation, produces long-lived, but latent, mutated cells that require chronic tumor promoter exposure to form cancers.

A longitudinal clinical study using intraoperative 13C-glucose infusions in patients with non–small cell lung cancer finds that use of glucose by tumors to supply the tricarboxylic acid cycle predicts ...

We evaluate cancer-protective effects of walnuts via formation of microbe-derived urolithin A, substantiating their functional benefits on serum inflammatory markers and immunologic composition of ...

BBO-8520, a dual inhibitor of KRASG12C in its GTP- and GDP-bound states, has a novel mechanism of action that enables effector blockade and optimal target coverage, even in growth factor activated ...

Copper promotes metabolic remodeling in clear cell renal cell carcinoma by enhancing mitochondrial respiration, biosynthesis, and detoxification, fueling tumor progression and offering a target for ...

Zongertinib, a covalent HER2 inhibitor, is active in HER2-driven preclinical models and patients and effectively targets HER2 oncogenic signaling while sparing wild-type EGFR, resulting in potent ...

Cell therapy, particularly the adoptive cell transfer of T cells genetically engineered with chimeric antigen receptors (CAR), illustrated the possibility of curative outcomes in hematologic B-cell ...

AbstractPurpose:. Claudin 18.2 (CLDN18.2) is a surface membrane protein that is crucial for maintaining tight junctions in gastric mucosal cells and is highly expressed in gastric, esophageal, and ...

ROPN1 is a highly expressed intracellular antigen in triple-negative breast cancer, and a T-cell receptor targeting ROPN1 enables sensitive and selective cancer cell recognition, supporting use as a ...

Abstract. Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options. Fucosyl-GM1 (FucGM1) is a glycolipid overexpressed in the majority of SCLC tumors but virtually absent ...