San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

Murray’s blooming connection with Harrison and tight end Trey McBride gives the Cards something to look forward to next fall, ...

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24 on Sunday.

From Phoenix breaking a daily heat record to new Arizona laws that went into effect, here are some of the Valley's top news stories from Jan. 3-5.

The San Francisco 49ers lost to the Arizona Cardinals on Sunday to put a stamp on what was one of the worst seasons of the Kyle Shanahan era. By falling to 6-11 on the year, the 49ers did secure the ...

Finally, the 2024 nightmare season for the San Francisco 49ers is over with. It ends in a blowout 47-24 loss to the Arizona ...

Kittle and McBride shared a strong embrace and short conversation before heading to the locker room. Upon the release of the ...

The Tennessee Titans have won the No. 1 overall pick in this summer’s draft after a historic season of losing. The Titans ...

Sunday afternoon's battle between the Arizona Cardinals and San Francisco 49ers was one of what could have been. Both San ...

The Arizona Wildcats (8-5) picked up their biggest win of the season Saturday, upsetting No. 16 Cincinnati 72-67 on the road.

Texas Longhorns safety Michael Taaffe has been at the center of controversy in the days following the 39-31 double-overtime win in the Peach Bowl agai ...

Kyler Murray tied a career high with four touchdown passes and did not throw an interception Sunday to lead the Arizona ...