Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

No Kittle means the 49ers will be down three All-Pros on offense. The club figured to rely heavily on him while McCaffrey and ...

George Kittle missed practice on Thursday because of a hamstring injury. Here's the latest on the TE's status for the Week 3 ...

Injuries can make or break your fantasy season. Here is the latest news on the NFL's biggest stars with injury questions ...

San Francisco 49ers left tackle Trent Williams found a possible silver lining in all the injuries the team is dealing with ...

Purdy still hasn't entirely shaken the "system" quarterback label and other denigrations. A chance for his rebuttal is now ...

Just as the San Francisco 49ers won’t miss seeing Aaron Donald lining up for the Los Angeles Rams on Sunday, Sean McVay won’t miss game planning against Christian McCaffrey and Deebo Samuel. Both ...

The San Francisco 49ers will be missing two of their biggest playmakers when they visit SoFi Stadium on Sunday to face the ...

Injuries have caused many problems for the San Francisco 49ers this year, and now Brock Purdy has lost another offensive ...

Defensive coordinator Nick Sorensen and run game coordinator and offensive line coach Chris Foerster reviewed the 49ers ...